Pharmacological action. The preparation suppresses the discharge of gonadotrophic hormones (hormones of the hypophysis, stimulating formations of hormones in sexual glands): luteinizing (a yellow body causing formation of ovary) and follicle-stimulating (stimulating maturing process of ovum). In greater dozes it renders moderated androgenic (similar action of male sexual hormones) and anabolic (strengthening synthesis of albumen) action.

Indications to application

In connection with antigonadotrophic (directed on decrease in function sexual glands) action it is used at treatment of endometriosis (occurrence in the various bodies of sites of a fabric similar by a structure with an internal environment of an uterus and exposed to cyclic changes accordingly to a menstrual cycle) with accompanying barreness, benign tumors of a mammary gland (a fibrocystic mastitis, etc.), a premenstrual syndrome (deterioration of state of health before the beginning of menstruation), gynecomastia (increases of mammary glands at men) and other diseases at which suppression of secretion of gonadotropin (the hormones of a hypophysis stimulating activity of sexual glands) is shown.

Contra-indications: Hypersensitivity, porphyria, a cancer of mammary glands, a cancer of prostate gland, genital bleedings (before specification of their reason), sharp renal or hepatic insufficiency, the expressed cardiac insufficiency, diabetes, epilepsy, migraine, infringements of plasma mechanisms of a hemostasis, pregnancy.

Collateral actions: Infringements of a menstrual function, reduction of the sizes of mammary glands, roughing of the voice, increase in weight of a body, hypostases, vaginitis, infringement of spermatogenesis, alopecia, erythema of face, hyperhidrosis, headaches, increase of intracranial pressure, lumbodynias, paresthesias, neurotic reactions, emotional lability, infringements of sleep, depression, frustration of sight, thrombocytosis or thrombocytopenia, erythrocytosis, leukocytosis, the raised danger of bleeding at patients with hemophilia, increase of the level of transaminase, cholestasis, hepatites, hepatoadenoma, dispeptic displays (seldom), seborrhea, acne, insignificant hirsutism, skin allergic reactions.

Safety measures: it is necessary to supervise periodically a level of transaminase and bilirubin in serum of blood. At purpose to diabetics the correction of a doze of insulin is necessary. During treatment the feeding mothers are recommended to stop breast feeding.